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4 edition of Comparative toxicity of N-nitrosodimethylamine and N-nitrosomethylbenzylamine in the rat found in the catalog.

Comparative toxicity of N-nitrosodimethylamine and N-nitrosomethylbenzylamine in the rat

Wei Chin

Comparative toxicity of N-nitrosodimethylamine and N-nitrosomethylbenzylamine in the rat

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Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.)--University of Toronto, 1991.

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches.
ID Numbers
Open LibraryOL21187438M
ISBN 100315653957
OCLC/WorldCa46527492

comparative evaluation of substrate effect on cumene hydroperoxide-dependent lipid peroxidation in mitochondria and microsomes; studies on the compartmental release of lipid peroxidation products in the perfused rat heart; ascorbic acid, lipid peroxidation and the interactions of drugs with their receptors in rat brain tissue preparations N’-nitrosonornicotine (NNN) is one of the tobacco-specific nitrosamines (TSNAs) that exists widely in smoke and smokeless tobacco products. NNN can induce tumors in various laboratory animal models and has been identified by International Agency for Research on Cancer (IARC) as a human carcinogen. Metabolic activation of NNN is primarily initiated by cytochrome P enzymes (CYPs) via 2 Year Citation Score; Wu Y, Liu C, Dong L, Zhang C, Chen Y, Liu J, Zhang C, Duan C, Zhang H, Mol BW, Dennis CL, Yin T, Yang J, Huang H. Coronavirus disease among pregnant Chinese women: Case series data on the safety of vaginal birth and breastfeeding. Bjog: An International Journal of Obstetrics and DOI: /?pid= Full text of "Scientific Criteria Document for Multimedia Standard Development N Ndma" See other formats


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Comparative toxicity of N-nitrosodimethylamine and N-nitrosomethylbenzylamine in the rat by Wei Chin Download PDF EPUB FB2

N-Nitrosodimethylamine and 1,2-dimethylhydrazine were shown to injure lethally primary monolayer cultures of rat hepatocytes only after incubation periods in excess of 24 toxic action of these agents, therefore, mimics the time dependency of their hepatoxicity in viability of hepatocytes treated with N-nitrosomethylbenzylamine was not different from controls at times up to 54 Comparative tumor initiating activities of N-nitrosomethylbenzylamine and N-nitrosodimethylamine in rat liver.

Labuc GE, Archer MC. The tumor initiating activities of nitrosomethylbenzylamine (NMBzA), an esophageal carcinogen, and nitrosodimethylamine (NDMA), a hepatocarcinogen, were compared in rat liver using modifications of the initiation N-Nitrosomethylethylamine concns of 1 to 40 ng/cigarette were detected in smoke condensate from various cigarettes and cigars(2).

N-Nitrosomethylethylamine levels of ng/cigarette were detected in the mainstream smoke of 20 commercial brands of filter and non-filter cigarettes(3); levels were much lower in the cigarette tobacco(3).

Metabolism of N-nitrosodimethylamine (NDMA), a hepatocarcinogen, and N-nitrosomethylbenzylamine (NMBeA), an esophageal carcinogen, was comparatively investigated in rat liver. When these nitrosamines (25 micromole/kg) were administered orally to rats, the clearance of NDMA from the serum and liver was faster than that of :// The enhancing effect of ethanol on the mutagenic activation of N-nitrosomethylbenzylamine by cytochrome P 2A in the rat oesophagus.

Tatematsu K(1), Koide A, Morimura K, Fukushima S, Mori Y. Author information: (1)Laboratory of Radiochemistry, Gifu Pharmaceutical University,Mitahora-higashi 5-chome, Gifu://   The purpose of this study was to determine whether quantitative differences in hepatic DNA methylation or ethylation are sufficient to explain differences in the carcinogenicity of N-nitrosomethylethylamine (NMEA), N-nitrosodimethylamine (NDMA), and N-nitrosodiethylamine (NDEA).

Methylation and ethylation of hepatic DNA were determined in male Fischer rats following a single N-nitrosodiethylamine is a nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.

It has a role as a mutagen, a hepatotoxic agent and a carcinogenic agent. N-nitrosodiethylamine is a clear slightly yellow liquid.

Boiling point °C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and Dietary freeze-dried black raspberries (BRBs) inhibit N-nitrosomethylbenzylamine (NMBA)-induced tumorigenesis in the Fischer rat determine the mechanistic basis of the anti-initiating effects of BRBs, NMBA metabolism was studied in esophageal explant cultures and in liver microsomes taken from rats fed with AINA diet or AINA diet containing 5% or 10% :// NCBI Bookshelf.

A service of the National Library of Medicine, National Institutes of Health. National Research Council (US) Committee on Comparative Toxicity of Naturally Occurring :// TOXICOLOGY AND APPLIED PHARMACOL () A Comparative Assessment of Toxic Effects of Dimethyinitrosamine in Six Different Species EMMANUEL N.

MADUAGWU AND OLUMBE BASSIR Department of Biochemistry, University of Ibadan, Ibadan, Nigeria Received March 8, ; accepted Octo A Comparative Assessment of Toxic Effects of Dimethylnitrosamine Comparative metabolism of N-nitrosopiperidine and N-nitrosopyrrolidine by rat liver and esophageal microsomes and cytochrome P 2A3 Article in Carcinogenesis 24(2) March with 31   There is little information on early molecular events in the development of N-nitrosomethylbenzylamine (NMBA)–induced rat esophageal tumorigenesis and of the effects of chemopreventive agents on these this study, we identified genes in rat esophagus that were differentially expressed in response to short-term NMBA treatment and modulated by cotreatment with Some 12 sites have been shown to be alkylated by various methyl- and eghylating agents: N-1, N-3, N-7 positions of adenine N-3, N-7 and O 6 of guanine, N-3, O 2 of cytosine and N 3, O 4, O 2 of thymine and the oxygens of the phosphate group.

The relative extents of alkylation depend upon the mechanism of alkylation, the agents reacting mainly Metabolic activation capabilities of S9 and hepatocytes from uninduced rats to convert carcinogenic N-nitrosamines to mutagens. Rumruen K, Pool BL.

6 carcinogenic nitrosamines were studied in Salmonella typhimurium TA after activation by S9 and by ://   There is little information on early molecular events in the development of N -nitrosomethylbenzylamine (NMBA)–induced rat esophageal tumorigenesis and of the effects of chemopreventive agents on these events.

In this study, we identified genes in rat esophagus that were differentially expressed in response to short-term NMBA treatment and modulated by cotreatment with Cancer Letters, 35 () Elsevier Scientific Publishers Ireland Ltd.

MICRONUCLEUS FORMATION INDUCED IN RAT LIVER AND ESOPHAGUS BY NITROSAMINES REKHA MEHTA',*, K. CHARLES SILINSKAS', PETER F. ZUCKER- AMIRAM RONENb, JOHN A. HEDDLa,** and MICHAEL C. ARCHER' 'Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Mechanism of Organ Specificity in Nitrosamine Carcinogenesis.

Authors; Comparative tumor initiating activities of N-nitrosomethylbenzylamine and N-nitrosodimethylamine in rat liver R., Labuc, G.E., Urbanski, S.J. and Archer, M.C.,Organ specificity in the microsomal aci:ivation and toxicity of N-nitrosomethylbenzylamine in Int.

Immunopharrnac., Vol.Elsevier Science Ltd Pergamon International Society for lmmunopharmacology Printed in Great Britain. - /94 $ + - (94)EI O6-METHYLGUANINE- DNA ADDUCTS IN RAT LYMPHOCYTES AFTER IN VIVO EXPOSURE TO N-NITROSODIMETHYLAMINE (NDMA) S.

FADLALLAH,* M. LACHAPELLE,* K. N-Nitrosodimethylamine (NDMA) has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based upon laboratory studies in which tumours have been induced in N-nitrosodimethylamine (NDMA), Liver Function Enzymes, Renal Function Parameters and Oxidative St ress Parameters: A Review 1 Usunobun Usunomena, 2 Adegbegi J.

Ademuyiwa, 1 Ethanol treatment also elevated the mutagenic activities of N-nitrosodimethylamine (DMN), DEN and N-nitrosopyrrolidine (NPYR) in strain TA up toand fold above each control TOXICOLOGICAL PROFILE FOR N-NITROSODIMETHYLAMINE Prepared by: Syracuse Research Corporation Under Subcontract to: Clement Associates, Inc.

Under Contract No. Prepared for: Agency for Toxic Substances and Disease Registry (ATSDR) U.S. Public Health Service In collaboration with U.S. Environmental Protection Agency (EPA) December ?Dockey=   Abstract. Short term in vivo studies were performed to study biological effects of the common air pollutants SO 2 or NO x and their influence on the genotoxic activities of nitrosamines.

Hepatocytes and lung cells were isolated from Sprague-Dawley rats which had inhaled 50 p.p.m. of SO 2 or NO x for 2 weeks. After incubating the cells for 1 h, genotoxicity was determined in hepatocytes by Abstract. Since when the carcinogenic activity of the first N-nitroso compound, nitrosodimethylamine, was reported by Magee and Barnes, (1) there has been growing interest in the biological activity of this group of compounds.

Extensive studies of the carcinogenic activity of N-nitroso compounds of various structures have been carried out with the aim of using the differences in activity Abstract.

It was discovered in the mids by Magee and Barnes that N-nitrosodimethylamine (NDMA) was carcinogenicity of this compound and many other nitrosamines has since been tested by Magee, Druckrey, Preussmann, Schmähl, and others; the results of these pioneer works were summarized in two comprehensive reviews (1,2).

Comp. Biochem. Physiol. Vol. C, No. 3, pp.Printed in Great Britain /91 $ + Pergamon Press pic ABSENCE OF O'-ALKYLGUANINE-DNA ALKYLTRANSFERASE INDUCTION IN CHICK EMBRYO LIVER AND BRAIN FOLLOWING X-IRRADIATION OR TREATMENT WITH BLEOMYCIN I. STAMMBERGER* and K. TEMPEL Institute of Pharmacology, Toxicology and   N-nitrosodimethylamine, N-nitrosopyrrolidine, or N'-nitrosonornicotine to nursing rats: their interactions with liver and kidney nucleic acids from sucklings.

J Nat1 Cancer Inst *Dickins M, Wright K, Phillips M, et al. Toxicity and mutagenicity of 6 anti-cancer drugs in Chinese hamster V79 cells co-cultured with rat :// This banner text can have markup.

web; books; video; audio; software; images; Toggle navigation Y Ohno's 47 research works with citations and reads, including: Sulfation of bisphenol A abolished its estrogenicity based on proliferation and gene expression in human breast cancer MCF-7   The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory :// Metabolism of N'-Nitrosonornicotine by Rat Liver, Oral Tissue, and Esophageal Microsomes.

Possible Mechanisms of N-Nitrosodimethylamine Hepatotoxicity. Michael C. Archer; Modulation of N-Nitrosomethylbenzylamine Metabolism in Rats by Concurrently Administered Ethanol and Diallyl ://   Microsomal Oxidation of N,N-Diethylformamide and Its Effect on PDependent Monooxygenases in Rat Liver.

Chemical Research in Toxicology9 (5), DOI: /txu. Niclas Tindberg and Magnus Ingelman-Sundberg. Cytochrome P and oxygen ://   Effect of phenobarbital and 3-methylcholanthrene on the hepatic microsomal metabolism of N-nitrosodimethylamine, N-nitrosomethylbutylamine and N-nitrosomethylbenzylamine.

Kawanishi T, Ohno Y, Takahashi A, Nakadate M, Takanaka A, Kasuya Y, Omori Y. Cancer Lett, 20(2), 01 Sep N-nitrosodimethylamine 0 N-nitrosodiethylamine 0 N-nitrosodi-n-butylamine 0 N-nitrosopyrrolidine 0 Risk Levels and Corresponding Criteria (1) 10 -7, pg/1, fig/1, jig/ /ig/1 10 ^ag/ pg/ ^g/ pg/1 10 ^ig/ pg/ p.g/ pg/1 (1)Calculated by applying a modified "one-hit ?Dockey=   The effects of ascorbic acid deficiency and excess on the metabolism and toxicity of N-nitrosodimethylamine and N-nitrosodiethylamine in the guinea pig.

Involvement of cytochrome P 2E1-like isoform in the activation of N-nitrosobis(2-oxopropyl)amine in the rat nasal mucosa European Journal of Cancer Part B: Oral Oncology, Vol. 30, No. 3 Nephrotoxicity Resulting from Multiple Chemical Exposures and Chemical Interactions   @article{osti_, title = {The carcinogenic danger of nitrite pollution of the environment}, author = {Rubenchik, B.L.

and Osinkovskaya, N.D. and Mikhailenko, V.M. and Furman, M.A. and Boim, T.M.}, abstractNote = {Presented are the literature data as well as the results of our own investigations on the genotoxic and carcinogenic effects of sodium nitrite (SN).

N-Methyl-N-nitrosomethanamine. CAS Number: Catalog Number: AA00F2XM. MDL Number: MFCD Molecular Formula: C2H6N2O. Molecular Weight: AA ://   subcutaneous-rat LD50 ug/kg Archives of Toxicology, Supplement. Vol. 14, Pg.Inhalation Toxicity: inhalation-rat LC50 ug/m3/4H Gigiena Truda i Professional'nye Zabolevaniya.

Labor Hygiene and Occupational Diseases. Vol. 16(10), Pg. 36, Although N-nitrosamines such as N-nitrosodimethylamine and N-nitroso- morpholine are rapidly and fairly evenly distributed throughout the bodies of rats after injection (Magee, ; Stewart, et al.

), the acute toxic damage they produce is more severe in the liver than elsewhere, and tumors following chronic exposure are confined mainly to ?Dockey=LNTXT. Haloacetonitriles (HANs) are toxic nitrogenous drinking water disinfection byproducts (N-DBPs) and are observed with chlorine, chloramine, or chlorine dioxide disinfection.

Using microplate-based Chinese hamster ovary (CHO) cell assays for chronic cytotoxicity and acute genotoxicity, we analyzed 7 HANs: iodoacetonitrile (IAN), bromoacetonitrile (BAN), dibromoacetonitrile (DBAN To assess the distribution of NDMA in the whole rat and the persistence of the induced DNA damage in the two organs, further studies were carried out after oral application of 1, 2, 4, 10, 20, 32 and 40 mg/kg to the animals.

Following 1 h exposure of rats to NDMA, the lowest effective genotoxic dose for lung and kidney was 2 mg NDMA/kg body ://  Abstract.

Black tea theafulvins, a fraction of thearubigins isolated from black tea aqueous infusions, potentiated the mutagenic activity of the mycotoxin aflatoxin B 1 in the Ames test, in the presence of a hepatic S9 activation system derived from Aroclor treated rats.

In contrast, when the S9 activation system was replaced with isolated microsomes, theafulvins suppressed the