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2 edition of Studies on the effects of acute and chronic hypoxia in experimental animals found in the catalog.

Studies on the effects of acute and chronic hypoxia in experimental animals

Andrew Suggett

Studies on the effects of acute and chronic hypoxia in experimental animals

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  • 13 Currently reading

Published .
Written in English


Edition Notes

Thesis (Ph.D.) - University of Sheffield, Dept. of Medicine, 1980.

StatementAndrew Suggett.
The Physical Object
Pagination343leaves,[2]leaves of plates
Number of Pages343
ID Numbers
Open LibraryOL13950303M

Dec 24,  · Then, we describe in detail the effect of IH in patients with OSA that we can consider "the human model" of chronic IH. In this way, we can better understand the specific pathophysiological mechanisms proposed to explain the consequences of IH in OSA. Keywords: hypoxia, intermittent hypoxia, experimental studies, obstructive sleep apnea. For the third and fourth doses of the groups the survival rate of the animals irradiated in conditions of hypoxia did not differ from that for the control mice irradiated normally. The relation between the protective effect of hypoxia and the radiation doses make it possible to embark on a quantitative assessment of the protective effect. Ambient air is composed of % oxygen, % nitrogen, % carbon dioxide, and less than 1% other gases (Lide ). Data collected on nine nuclear-powered ballistic missile submarines indicate an average partial pressure of oxygen (PO 2, the product of the barometric pressure and the percentage of oxygen in the ambient atmosphere) of millimeters of mercury (mmHg) and a range of Acute Intermittent Hypoxia and Body Weight Supported Treadmill Training for Incomplete Spinal Cord Injury Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.


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Studies on the effects of acute and chronic hypoxia in experimental animals by Andrew Suggett Download PDF EPUB FB2

There have been numerous studies that have examined the effects of acute and chronic hypoxia on human cognitive performance (for reviews, see the study by Yan 48). The settings of these studies have been high-altitude research expeditions, hypobaric chambers, or breathing systems involving controlled levels of hypoxemia in the laboratory.

Although a significant effect of acute hypoxia was observed in two of the populations tested, there was no. observable effect of seven days of hypoxia on these fish. This suggests that fish from INM and PMB were able to.

adjust to hypoxia over the longer period of exposure. Jul 24,  · Walker et al. used chronic preparation models to show that heart rate responses to an acute onset of hypoxia depend on the stage of fetal development.

9 Before term, the change in the fetal heart during hypoxia is insignificant. From to term, bradycardia occurs in response to inovelpapery.icu: Yasuyuki Kawagoe, Hiroshi Sameshima. Chapter 2: Skeletal muscle phenotypic plasticity during chronic hypoxia and its effects on whole animal muscle metabolism during acute exercise in small mammals.

Authors: Alex D. Connaty and Grant B. McClelland Date of planned submission: April, Comments: This study was conducted by ADC under the supervision of inovelpapery.icu: Alex D. Connaty.

Given the expanding threat of hypoxia for marine organisms including cod (Breitburg, ; Neuenfeldt, ; Wu et al., ; Gilbert et al., ), and our incomplete understanding of fish physiology when exposed to low oxygen conditions, the main goal of the present study was to determine whether Atlantic cod are able to adapt to chronic inovelpapery.icu by: The first study in which the behavioral effects of tyrosine were examined in humans subjected to acute stress was conducted at USARIEM (Banderet and Lieberman, ).

The experimental stressor was acute exposure (4 h) to a combination of hypobaric hypoxia (4, and 4, m [13, and 15, ft]) and cold (15°C [60°F]).Cited by: Acute, sub-chronic oral toxicity studies and evaluation of antiulcer activity of Sooktyn in experimental animals Phool Chandra, Neetu Sachan, 1 Kamal Kishore, 2 and Ashoke Kumar Ghosh 3 Department of Pharmacology, School of Pharmaceutical Sciences, IFTM University, Lodhipur Rajput, Moradabad, Uttar Pradesh, India.

present, studies on the effects of chronic (weeks of) hypoxia have been conducted on a limited number of teleost species, and focused on a range of aspects such as food intake (Chabot and Dutil. Apr 27,  · The present review attempts to examine together the research paradigms and clinical studies on the effect of acute and chronic IH and the potential link with OSA.

We firstly describe the literature data on the mechanisms activated by acute and chronic IH at the experimental level, which are very helpful and beneficial to explaining OSA Cited by: Mar 29,  · In addition to differing hypoxia levels, exposure times used to induce in vitro and in vivo experimental acute and chronic hypoxia range from 30 min to several weeks with no clear boundaries separating the two.

Evaluation of the biological consequences of each hypoxia subtype revealed a general trend that acute hypoxia leads to a more aggressive inovelpapery.icu by: Effects observed in chronic toxicity studies should be considered with respect to both their statistical and their biological significance.

One should not rely on statistical significance alone, especially when only a few animals are assigned per group as is the norm in nonrodent studies. The effects of acute and chronic hypoxia on cortisol, glucose and lactate concentrations in different populations of three-spined stickleback November Fish Physiology and Biochemistry 37(3) Recent studies at severe altitude (5, m) documented that a chronic exposure to hypoxia (CH), which is associated with a substantial recovery of arterial O 2 saturation and content, can attenuate the development of central fatigue, but does not recover the exacerbated rate of development of peripheral fatigue observed during exercise in AH (19, 20).Cited by: In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus to study the effects of acute and chronic hypoxia on the clinical reports and experimental.

Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain Article in Developmental Brain Research (1) · July with 38 Reads. Aug 01,  · Effect of chronic hypoxia on SMC. Chronic hypoxia leads to proliferation of PASMC in vivo. Histological and morphological analysis of PAs of animals exposed to chronic hypoxia, and humans who died from high altitude PH, showed a significant thickening of the muscular layers 42, Chronic hypoxia also causes extension of SMC into normally nonmuscular inovelpapery.icu by: It was pointed out that the clear-cut experimental conditions of the isolated perfused rat brain may be particularly useful for studies on energy metabolism.

Electrophoretically, there was a general tendency of LDH-1 and other anodal isoenzymes to rise. Thus, chronic hypoxia did entail changes of LDH regarding both its subcellular. Ventilation and oxygen consumption were measured in awake, unrestrained and unintubated guinea pigs during chronic and acute exposure to cold or hypoxia.

Specific '~E and '~o~ in acute and chronic exposure to cold were more than twice that of animals in normal environmental inovelpapery.icu by: sue hypoxia, the effects of oxygen deficiency on the var-ious organ systems of the body, and the clinical manifestations of chronic hypoxia in different contexts.

Pertinent to the context of this conference, the last section focuses in some detail on the effects of chronic hypoxia in patients with chronic obstructive pulmonary disease (COPD).

Cardiac Adaptive Responses After Hypoxia in an Experimental Model the effects of acute and chronic hypoxia on the coronary vasculature and coronary blood inovelpapery.icur 1 included a section. Abstract.

Experimental studies in extreme hypoxic conditions affecting the brain have been performed mainly in acute but not chronic models. Twenty rats were housed and exposed to decreasing concentrations of oxygen (from 21% to 7% over days) and ten normal rats were used as inovelpapery.icu by: 8. No studies, to date, have evaluated the effects of acute hypoxia exposure on memory interference, which was the purpose of this experiment.

Methods: A within-subjects, counterbalanced experimental design was employed, with condition (hypoxia vs. normoxia) and time (immediate vs. delayed) being the independent inovelpapery.icu: Paul D. Loprinzi, Aala’a Matalgah, Lindsay Crawford, Jane J. Yu, Zhaowei Kong, Bo Wang, Shijie Liu.

Because endothelial cells are positioned such that they should be the initial cell within the vascular wall to detect a change in blood oxygen concentration, studies on the effect of acute and chronic hypoxia on these cells might define the oxygen-sensing mechanisms and uncover the inherent differences between aortic and pulmonary arterial Cited by: 2.

Consistent with the effect of acute fetal hypoxia, chronic hypoxia induced by SUAL was associated with significantly increased concentrations of activin A in the AF.

However, there are important differences in the results of the current study and those previously reported in acute hypoxia inovelpapery.icu by: Studies have shown that both acute and chronic hypoxia induce an upregulation in the gene expression of VEGF, and its receptors (KDR/Flk and Flt) in the animal models of prolonged hypoxia-induced pulmonary hypertension.

In fact, the increase in the VEGF gene expression was seen as early as 2 h upon hypoxic challenge in isolated and perfused rat lungs while chronic hypoxia resulted in greater Author: Sandeep Artham, Payaningal R.

Somanath. Jun 01,  · In this study, we assess the effects of both acute and chronic ethanol exposure on anxiety-like behaviors in zebrafish, using two behavioral paradigms, the novel tank diving test and the light/dark choice assay. Acute ethanol exposure exerted significant dose-dependent anxiolytic inovelpapery.icu by: We reviewed the effects of chronic hypobaric hypoxia as well as chronic anemia in the heart and brain, and we compared for the first time the effects of chronic hypobaric hypoxia combined with a severe lack of Epo (chronic anemia) in these vital organs.

Adaptations to Chronic Hypoxia Combined with Erythropoietin Deficiency in Cerebral and Author: Raja El Hasnaoui-Saadani. Feb 01,  · Questions exist concerning the effects of acute versus chronic hypoxic conditions on DNA replication and genomic stability that may influence tumorigenesis.

Severe hypoxia causes replication arrest independent of S-phase checkpoint, DNA damage response, or transformation status. Arrests occur during both the initiation and elongation phases of DNA replication, correlated with a. subacute and chronic effects following long-term exposure.

Chronic Effects Following Acute Exposure Acute pesticide intoxications may leave recovered individuals with residual neuro-logic impairment, particularly if they result in multiorgan failure or nervous system hypoxia.

Such outcomes are noted for individual agents elsewhere in this document. The physiology of chronic hypoxia encompasses an enormous field of knowledge. This review concentrates on two areas in which important advances have recently been made.

The first is hypoxia Cited by: Hypoxia has been shown to increase the aggressiveness and severity of tumor progression. Along with chronic and acute hypoxic regions, solid tumors contain regions of cycling hypoxia (also called intermittent hypoxia or IH).

Cyclic hypoxia is mimicked in vitro and in vivo by periodic exposure to cycles of hypoxia and reoxygenation (H–R cycles).Cited by: 3. Dec 10,  · Animal Studies. Studies on the neurological effects of acute TCE inhalation in animals have produced results similar to human studies (Agency for Toxic Substances and Disease Registry ).

Hepatic and Renal Effects: When swallowed, TCE causes gastrointestinal (GI) irritation, with possible inflammation of the GI tract, manifested as. Chronic hypoxia is associated with elevated sympathetic activity and hypertension in patients with chronic pulmonary obstructive disease.

However, the effect of chronic hypoxia on systemic and regional sympathetic activity in healthy humans remains inovelpapery.icu by: In Veterinary Medicine (Eleventh Edition), Cerebral Hypoxia.

Cerebral hypoxia occurs when the supply of oxygen to the brain is reduced for any reason. An acute or chronic syndrome develops depending on the acuteness of the deprivation. Initially there are irritation signs followed terminally by signs of loss of function.

In doing so he finds himself in a peculiar situation: he treats acute and chronic hypoxia of varying degrees and many times he can ascertain the correctness of his treatment only on the basis of the clinical success without having at his disposal verified experimental inovelpapery.icu by: 4.

Acute vs chronic hypoxia: what are the consequences for skeletal muscle mass. Hypoxia is a state of lowered oxygen tension that can be created by environmental or pathological conditions.

Regardless the origin of hypoxia, skeletal muscle cells adapt to deal with the acute or chronic. Most solid human tumours contain regions of acute and chronic hypoxia or anoxia that can herald a negative clinical prognosis for the cancer patient owing to local resistance and systemic inovelpapery.icu by: Mar 01,  · Low water oxygen content (hypoxia) is a common feature of many freshwater and marine environments.

However, we have a poor understanding of the degree to which diminished cardiac function contributes to the reduction in fish swimming performance concomitant with acute exposure to hypoxia, or how fish cardiorespiratory physiology is altered by, or adapts to, chronic inovelpapery.icu by: Exposure to intermittent hypoxia for 6 to 8 hours in the hour time clock over days or weeks, termed chronic intermittent hypoxia (CIH), as noted earlier in association with OSA in humans, often is used in experimental settings.

A wide array of intermittent hypoxia regimens is used in different laboratories, which may partly explain the. Feb 06,  · Hypoxia damages multiple organ systems especially those with high oxygen utilization such as the central nervous system.

The purpose of this study was to compare the neuropathological and neuropsychological effects of hypoxia in patients with either carbon monoxide poisoning or obstructive sleep inovelpapery.icu by:.

Apr 01,  · In this issue of Clinical Cancer Research, Rofstad et al. report on the significance of chronic (diffusion-limited) and acute (fluctuating or perfusion-limited) hypoxia in D and R human melanoma xenografts on the development of metastatic inovelpapery.icu tumors may contain different subpopulations of hypoxic cells has been known for many inovelpapery.icu by: Hypoxia, decreased oxygen availability, may serve as a model to help elucidate the pathophysiological basis of the metabolic encephalopathies.

These disorders, in which brain metabolism is altered.A persistent diestrous phase and a significant decrease in body weight were found in chronic hypoxia groups.

Histological study suggested degenerative changes in ovarian corpus luteum of 7 days.